• Título:  QUALITY-BY-DESIGN APPROACH FOR THE DEVELOPMENT OF LIPID-BASED NANOSYSTEMS FOR ANTI-MYCOBACTERIAL THERAPY
• Autor:  Rouco Taboada, Helena
• Universidad:  Universidad de Santiago de Compostela
• Departamento:  Escuela de Doctorado Internacional (EDIUS)
• Fecha de Lectura:  11/03/2021
• Mención Europeo / Mención Internacional: concedido
• Programa de doctorado:  Programa de Doctorado en Investigación y Desarrollo de Medicamentos por la Universidad de Santiago de Compostela
• Dirección: 
  • Landín Pérez, Mariana (DIRECTOR)
  • Remuñán López, Carmen (CODIRECTOR)
• Tribunal: 
  • TORRES SUAREZ, ANA ISABEL (PRESIDENTE)
  • GARCÍA GONZÁLEZ, CARLOS ALBERTO (SECRETARIO)
  • Moutinho Grenha, Ana Margarida (VOCAL)
• Descriptores: 
  • COMPOSICION DE FARMACOS
  • PREPARACION DE FARMACOS
  • INTELIGENCIA ARTIFICIAL
• Localización:  BIBLIOTECA XERAL USC
• 522015_1303046.pdf
• Resumen:
  In this work, we rationally developed a lipid-based nanotechnological platform for hydrophobic anti-mycobacterial drugs. For this purpose, Artificial Intelligence tools were employed to assist formulation development, from the initial design to its conversion into a solid dosage form. Reproducible nanocarriers exhibiting suitable properties were achieved through a simple and robust procedure. Furthermore, the analysis of their in vitro performance revealed promising results in terms of permeability, cell uptake and selective intracellular release. Thus demonstrating the potential of these nanosystems to treat intestinal intracellular infections, increasingly related with Crohn¿s disease development.