• Título:  NEUROPROTECTIVE EFFECTS OF POTENT ANTIOXIDANT MOLECULES ISOLATED FROM BIFURCARIA BIFURCATA AND CODIUM TOMENTOSUM IN AN IN VITRO AND IN VIVO PARKINSON DISEASE MODEL
• Autor:  Martins da Silva, Joana Rita
• Universidad:  Universidad de Santiago de Compostela
• Departamento:  Escuela de Doctorado Internacional (EDIUS)
• Fecha de Lectura:  11/11/2021
• Programa de doctorado:  Programa de Doctorado en Ciencias Marinas, Tecnología y Gestión por la Universidad de A Coruña; la Universidad de Santiago de Compostela; la Universidad de Vigo; Universidade de Aveiro(Portugal); Universidade de Trás-os-Montes e Alto Douro(Portugal); Universidade do Minho (Portugal) y Universidade do Porto(Portugal)
• Dirección: 
  • Pinto Pedrosa, Rui Filipe (DIRECTOR)
  • ALFONSO RANCAÑO, MARIA AMPARO (CODIRECTOR)
  • SÁNCHEZ LÓPEZ, JOSÉ LUIS (TUTOR/PONENTE)
• Tribunal: 
  • Botana López, Luis M (PRESIDENTE)
  • Oliveira Vasconcelos, Vitor Manuel (SECRETARIO)
  • Gaudêncio, Susana (VOCAL)
• Descriptores: 
  • CULTIVO CELULAR
  • FITOFARMACOS
  • MECANISMOS DE ACCION DE LOS FARMACOS
• Localización:  BIBLIOTECA XERAL USC
• 604053_1379070.pdf
• Resumen:
  The potential of marine-derived compounds isolated from two seaweeds for the treatment of Parkinson¿s disease has been evaluated, with a focus on four key pathological ¿ mechanisms, stress oxidative, mitochondrial dysfunction, apoptosis and inflammation. The eleganolone and loliolide compounds presented neuroprotective affects, preserving the stress condition, mitochondrial function and a inhibition apoptotic process . Moreover, the modulated the macrophage inflammatory response, which enhances their protective effects. The promising results obtained, showed that marine-derived revealed to be them promising candidates as anti-Parkinson's drugs.