• Título:  ROLE OF RBM3 IN CEREBRAL ISCHEMIA
• Autor:  Ávila Gómez, Paulo
• Universidad:  Universidad de Santiago de Compostela
• Departamento:  Escuela de Doctorado Internacional (EDIUS)
• Fecha de Lectura:  07/04/2022
• Mención Europeo / Mención Internacional: concedido
• Programa de doctorado:  Programa de Doctorado en Medicina Molecular por la Universidad de Santiago de Compostela
• Dirección: 
  • CAMPOS PÉREZ, FRANCISCO (DIRECTOR)
  • Castillo Sánchez, José (CODIRECTOR)
  • ZALDIVE TORRENTE, JUAN (TUTOR/PONENTE)
• Tribunal: 
  • GUTIÉRREZ FERNÁNDEZ, MARÍA (PRESIDENTE)
  • Hervella Lorenzo, Pablo (SECRETARIO)
  • Morâo Cabral Ferro, Jose Manuel (VOCAL)
• Descriptores: 
  • NEUROFISIOLOGIA
  • NEUROLOGIA
  • NEUROPATOLOGIA
• Localización:  BIBLIOTECA XERAL USC
• 629508_1425668.pdf
• Resumen:
  Stroke is the second leading cause of death worldwide with an ever-increasing incidence. Despite the advances in experimental research and clinical management, the only available drug for ischemic stroke is the tissue plasminogen activator. Although hypothermia is a promising therapeutic strategy against cerebral ischemia, its associated adverse effects hamper its clinical application. In this regard, cold shock proteins could become a valuable tool without said downsides. The present work provides clinical evidence on the effects of hypothermia on the expression of RBM3 and the outcome of patients, and explores the influence of temperature on FGF21 (a novel RBM3 inductor) and RBM3 levels in obese stroke patients. Moreover, we studied the protective effect of hypothermia and RBM3 in a mice model of cerebral ischemia.