• Título:  QUORUM SENSING AND ORAL BIOFILM: AN ALTERNATIVE FOR THE PREVENTION AND TREATMENT OF ORAL DISEASES
• Autor:  Parga Martínez, Ana
• Universidad:  Universidad de Santiago de Compostela
• Departamento:  Escuela de Doctorado Internacional (EDIUS)
• Fecha de Lectura:  17/02/2023
• Mención Europeo / Mención Internacional: concedido
• Programa de doctorado:  Programa de Doctorado en Avances en Biología Microbiana y Parasitaria por la Universidad de Santiago de Compostela
• Dirección: 
  • OTERO CASAL, ANA MARÍA (DIRECTOR)
• Tribunal: 
  • CÁMARA GARCÍA, MIGUEL MARÍA (PRESIDENTE)
  • Balboa Méndez, Sabela (SECRETARIO)
  • León Berríos, Rubén (VOCAL)
• Descriptores: 
  • MICROBIOLOGIA
• Localización:  BIBLIOTECA XERAL USC
• 694590_1579924.pdf
• Resumen:
  The present thesis investigates the potential of inhibiting bacterial cell-cell communication, quorum sensing (QS), to modulate oral biofilm formation. The thesis evaluates the effect of a quorum quenching (QQ) enzyme that degrades N-acylhomoserine lactones, the QS signals of gram-negative bacteria, on in vitro polymicrobial oral biofilms. The potential interactions between AHLs and a gram-positive representative, Enterococcus faecalis, were also investigated. The results presented here support the translation of QQ strategies to in vivo trials for the modulation of oral biofilms. In addition, a more intricate role of AHLs on oral biofilm formation and interactions with gram-positive bacteria is proposed.