• Título:  NOVEL APPROACHES FOR THE DISCOVERY OF PHARMACOGENETIC BIOMARKERS OF CHEMOTOXICITY IN PATIENTS WITH COLORECTAL CANCER
• Autor:  Santos Simoes, Ana Rita
• Universidad:  Universidad de Santiago de Compostela
• Departamento:  Escuela de Doctorado Internacional (EDIUS)
• Fecha de Lectura:  16/10/2023
• Mención Europeo / Mención Internacional: concedido
• Programa de doctorado:  Programa de Doctorado en Medicina Molecular por la Universidad de Santiago de Compostela
• Dirección: 
  • Fernández Rozadilla, Ceres (DIRECTOR)
  • CARRACEDO ALVAREZ, ANGEL MARIA (CODIRECTOR)
• Tribunal: 
  • López Fernández, Luis (PRESIDENTE)
  • BARROS ANGUEIRA, FRANCISCO (SECRETARIO)
  • Palles, Claire (VOCAL)
• Descriptores: 
  • GENETICA HUMANA
• Localización:  BIBLIOTECA XERAL USC
• 741828_1652396.pdf
• Resumen:
  Colorectal cancer (CRC) is often linked to adverse drug reactions (ADRs), which can be severe or even fatal. To address this issue, pharmacogenetic studies have emerged to help personalise treatments based on molecular information. However, these have been limited by a lack of standardized data, the complexity of ADR phenotyping and the need for novel strategies and functional assays. Therefore, the aim of this project was to find and validate new CRC chemotoxicity biomarkers, using state-of-the-art approaches. We have conducted different omic analyses to identify low to high-penetrance variants and performed in vitro assays on a variant of interest. Our work successfully identified several candidate toxicity variants/genes that might be influencing the development of ADRs in CRC patients.