Tesis doctorales: TESEO

Ayuda Salir

Ficha de Tesis

Imprimir

Ministerio de Universidades - Gobierno de España

Título: NEW FUNCTIONAL LIGANDS FOR THE PREPARATION OF PHOTOACTIVE NANOPARTICLE-BASED MATERIALS
Autor: Amorín Ferré, Laura
Universidad: Universidad Autónoma de Barcelona
Departamento: Quimica
Fecha de Lectura: 04/12/2014
Programa de doctorado: Quimica
Dirección:
- HERNANDO CAMPOS, JORDI (DIRECTOR)
- BOURDELANDE FERNANDEZ, JOSÉ LUIS (CODIRECTOR)
- Busqué Sánchez, Félix (CODIRECTOR)
Tribunal:
- PLEIXATS ROVIRA, ROSER (PRESIDENTE)
- Imaz, Inhar (SECRETARIO)
- Galian, Raquel E (VOCAL)
Descriptores:
- FOTOQUIMICA
- SINTESIS QUIMICA
Localización: BIBLIOTECA DE COMUNICACIÓN Y HEMEROTECA GENERAL UAB

2014amorinewfu.pdf

Marcador: https://www.educacion.gob.es/teseo/mostrarRef.do?ref=1119762Añadir a favoritos.
Resumen:
Nanoscience and nanotechnology are the novel disciplines emerged at the new millennium. The abilities for designing, fabricating and applying nanostructures and nanomaterials have revolutionized physics, chemistry, technology and biology. The present PhD thesis is focused on these fields. In particular, the design, synthesis and characterization of different organic ligands have been the main goal of the current work for (i) introducing them into coordination polymer particles (CPPs) and studying drug delivery processes, or (ii) stabilizing semiconductor nanoparticles, or quantum dots (QDs), and linking them in an ordered and controlled manner. CPPs are metaloorganic nanoparticles that have been proposed as potential drug carriers or contrast agents in the field of medicine. Even though many scientists have demonstrated CPPs are efficient carriers and delivers, to date no rational study exists for the drug delivery mechanisms. In view of this, the main objective of the first project of this PhD thesis is to rationally establish the release mechanisms of a drug from those systems. In this way, different fluorescent organic ligands have been designed, synthesized and characterized for introducing them into the CPPs and studying the delivery mechanisms by means of fluorescence measurements. Analysis of the obtained results demonstrates a fast diffusion of the drug (during the first hours of release) and slower degradation processes. By selectively monitoring the release kinetics of those fluorophores, we have not only demonstrated the occurrence of such mechanisms, but also assessed for the first time their individual efficiencies in view of the rational design of future systems with tailored drug delivery profiles. On the other hand, QDs are crystalline and colloidal semiconductor nanoparticles with unique optoelectronic properties, which can be modulated by finely tuning their composition, size or shape. QDs have been applied in the preparation of light emitting diodes (LEDs) and of solar cells. The present PhD thesis aims to the formation of new QD-based photonic nanowires for the efficient and unidirectional transport of excitation energy between the different QDs. Our approach relies on the functionalization of the semiconductor nanoparticles with ligands bearing azide and cyclooctyne groups, which can undergo Cu-free, strain-promoted azide-alkyne cycloaddition (SPAAC) under standard ambient conditions. As a first step towards the fabrication of future nanophotonic devices, we aimed herein to demonstrate the viability and potential of this synthetic strategy to conduct the controlled assembly of quantum dots. The obtained results demonstrated SPAAC-induced formation of QD heteroaggregates, which showed high energy transfer efficiences. This work opens up the door for future application of this methodology to the construction of 1D assemblies of well-ordered QDs.

Imprimir

Modificar Consulta Nueva Consulta

Versión 4.4