Tesis doctorales: TESEO

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Ministerio de Universidades - Gobierno de España

Título: APPLICATION OF DATA MINING AND ARTIFICIAL INTELLIGENCE TECHNIQUES TO MASS SPECTROMETRY DATA FOR KNOWLEDGE DISCOVERY
Autor: López Fernández, Hugo
Universidad: Universidad de Vigo
Departamento: Escuela Superior de Ingeniería Informática
Fecha de Lectura: 29/03/2016
Mención Europeo / Mención Internacional: Concedido
Programa de doctorado: Programa Oficial de Doctorado en Sistemas Software Inteligentes y Adaptables
Dirección:
- REBOIRO JATO, MIGUEL (DIRECTOR)
- González Peña, Daniel (DIRECTOR)
Tribunal:
- Peixoto Igrejas, Gilberto Paulo (PRESIDENTE)
- DÍAZ GÓMEZ, FERNANDO (SECRETARIO)
- García Lourenço, Anália María (VOCAL)
Descriptores:
- INFORMATICA
- INTELIGENCIA ARTIFICIAL
Marcador: https://www.educacion.gob.es/teseo/mostrarRef.do?ref=1217355Añadir a favoritos.
Resumen:
Mass spectrometry using matrix assisted laser desorption ionization coupled to time of flight analyzers (MALDI-TOF MS) has become popular during the last decade due to its high speed, sensitivity and robustness for detecting proteins and peptides. This allows quickly analyzing large sets of samples are in one single batch and doing high-throughput proteomics. In this scenario, bioinformatics methods and computational tools play a key role in MALDI-TOF data analysis, as they are able handle the large amounts of raw data generated in order to extract new knowledge and useful conclusions. A typical MALDI-TOF MS data analysis workflow has three main stages: data acquisition, preprocessing and analysis. Although the most popular use of this technology is to identify proteins through their peptides, analyses that make use of artificial intelligence (AI), machine learning (ML), and statistical methods can be also carried out in order to perform biomarker discovery, automatic diagnosis, and knowledge discovery. In this research work, this workflow is deeply explored and new solutions based on the application of AI, ML, and statistical methods are proposed. In addition, an integrated software platform that supports the full MALDI-TOF MS data analysis workflow that facilitate the work of proteomics researchers without advanced bioinformatics skills has been developed and released to the scientific community.

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