Tesis doctorales: TESEO

Ayuda Salir

Ficha de Tesis

Imprimir

Ministerio de Universidades - Gobierno de España

Título: BIOCOMPATIBILITY OF NEW BIOMATERIALS FOR ORTHOPAEDICAL APPLICATIONS
Autor: Blanquer Jerez, Andreu
Universidad: Universidad Autónoma de Barcelona
Departamento: Biologia cel-lular fisiologia i d'immunologia
Fecha de Lectura: 09/06/2016
Mención Europeo / Mención Internacional: Concedido
Programa de doctorado: Programa Oficial de Doctorado en Biología Celular
Dirección:
- NOGUÉS SANMIQUEL, CARME (DIRECTOR)
- IBÁÑEZ DE SANS, Mª ELENA (DIRECTOR)
- Barrios Sanromà, Lleonard (DIRECTOR)
Tribunal:
- SURIÑACH CORNET, SANTIAGO (PRESIDENTE)
- Monjo Cabrer, Marta (SECRETARIO)
- Filová, Elena (VOCAL)
Descriptores:
- ALEACIONES
- BIOLOGIA CELULAR
Localización: BIBLIOTECA DE COMUNICACIÓN Y HEMEROTECA GENERAL DE LA UAB

260541_838242.pdf

Marcador: https://www.educacion.gob.es/teseo/mostrarRef.do?ref=1257363Añadir a favoritos.
Resumen:
The use of biocompatible materials has attained an increasing importance for medical surgery and orthopaedics due to population aging. Metallic alloys currently used in bone implants have physical and mechanical properties different from those of the bone, which increases the probability of implant loosening. For this reason, new metallic alloys with better properties are being developed. In this regard, the present thesis aims to analyse the biocompatibility of new biomaterials for orthopaedic applications. First, we demonstrated the biocompatibility of TiZrCuPd bulk metallic glass in terms of cytotoxicity, and osteoblast adhesion and differentiation. Second, we assessed the effect of surface modification of TiZrCuPd and Ti-6Al-4V alloys by chemical and physical modification on osteoblast behaviour. Differences in topography (mirror-like, microscratched and nanomesh) did not cause changes on osteoblasts adhesion, proliferation and differentiation. Third, we demonstrated that TiZrPdSi and TiZrPdSiNb alloys are also biocompatible and enhance osteoblasts adhesion, spreading, proliferation and differentiation. Fourth, we evaluated the electrostimulation effect of two new ZnO piezoelectric nanogenerators using two cell lines involved in bone regeneration (osteoblasts and macrophages). We observed that both nanogenerators are biocompatible and that their interaction with cells produces a local electric field that stimulate macrophages motility and the increase in intracellular Ca2+ concentration in osteoblasts. Thus, these new smart materials have interesting properties for their use in biomedical devices. Collectively, the results obtained in our studies contribute to the progress in the development of better materials for bone repair and regeneration.

Imprimir

Modificar Consulta Nueva Consulta

Versión 4.4